Wednesday, 3 September 2008

Hef�s door open for Anderson






Playboy king Hugh Hefner has offered Pamela Anderson the use of his residence if she ever finds herself homeless, imdb.com reports.

The Baywatch star has appeared on numerous Playboy covers, and the 41-year-old knows she can bank on Hefner to place her up if she ever finds herself with nowhere to stay.

�(I asked Hefner) if ever anything goes untimely, I tin come and live here, can�t I?� she says.
Hefner replied: �Yes, of course. You are always receive at my place.�








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Sunday, 24 August 2008

Neurologix Initiates Recruitment For Phase 2 Parkinson's Disease Trial

�Neurologix, Inc. (OTCBB:NRGX), a biotechnology troupe engaged in the development of innovative gene therapies for the brain and central neural system, announced that it has received Institutional Review Board approvals to begin recruiting and enrolling participants for its Phase 2 clinical trial of the company's gene transfer glide slope to the treatment of advanced Parkinson's disease. The study is designed to evaluate the safety and efficacy of a novel non-dopaminergic approach for reestablishing motor function in Parkinson's patients wHO are sub-optimally responsive to drug therapies.


The randomized, double-blind, sham-procedure controlled tryout will involve up to 10 in the lead academic enquiry centers crossways the United States, with the first sites being Massachusetts General Hospital and Wake Forest University Health Sciences. Neurologix expects to enroll a total of 40 study participants in the trial. Twenty participants will receive an infusion of the gene-based handling bilaterally via a catheter temporarily placed in each subthalamic nucleus (STN) (a deep brain structure that is the main target of operating room to treat Parkinson's disease) by stereotactic surgery. The other 20 participants will receive aseptic saline solution into a partial thickness burr hole made into the skull, with no brain infusion.


Study participants will be assessed for treatment effects by standardised Parkinson's disease ratings at multiple time points post-procedure. The main endpoint for the study will be a clinical assessment of motor office at 6 months victimisation the Unified Parkinson's Disease Rating Scale (UPDRS). All participants in the study will too be monitored for base hit for 12 months following the cistron transfer operation. If the primary end point is met following the analysis of 6 month data, then the sham-control participants will be offered the opportunity to crossover into an open label study of the Neurologix gene transpose therapy if they continue to adjoin all accounting entry, medical and surgical criteria.


"Parkinson's disease is a devastating sickness for those patients whose symptoms are no longer well controlled by medication alone," aforementioned John Mordock, President and Chief Executive Officer of Neurologix. "We are very pleased to initiate this study, which may offer a new therapeutic option that is potentially disease modifying and more reproducible with the brain's normal metabolic activity."


For inside information about participating in the clinical trial, please see here.

About the Neurologix Gene Transfer Approach to Parkinson's Disease


In Parkinson's disease, patients lose dopamine-producing brain cells, which results in significant reductions in the natural process and sum of money of GABA (gamma-aminobutyric acid), a major inhibitory neurotransmitter in the brain that helps 'quiet' excessive neuronic firing. This reduction in GABA causes a disfunction in encephalon circuitry responsible for coordinating movement. GABA is made by a gene called glutamic caustic decarboxylase, or GAD.


Neurologix's gene transfer approach to Parkinson's disease seeks to restore GABA -- and thus better the patient's motor ascendency -- by inserting the GAD factor back into an area of the brain called the subthalamic nucleus, a key regulative center for movement.

About Neurologix


Neurologix, Inc. (NRGX.OB) is a clinical-stage biotech company consecrated to the discovery, growth, and commercialisation of life-altering gene transplant therapies for serious disorders of the brain and central nervous system (CNS). Neurologix's healing approach is built upon the groundbreaking research of its scientific founders and advisors, whose accomplishments have formed the foundation of gene therapy for neurological illnesses. Current company programs address such conditions as Parkinson's disease, epilepsy and Huntington's chorea, all of which ar large markets not adequately served by current alterative options. For more information, please visit the Neurologix website at http://www.neurologix.net.

Cautionary Statement Regarding Forward-looking Statements


This news release includes sure statements of the Company that whitethorn constitute "forward-looking statements" inside the import of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and which are made pursuant to the Private Securities Litigation Reform Act of 1995. These forward-looking statements and other information relating to the Company ar based upon the beliefs of direction and assumptions made by and entropy currently usable to the Company. Forward-looking statements include statements concerning plans, objectives, goals, strategies, future events, or performance, as well as underlying assumptions and statements that are other than statements of historic fact. When used in this text file, the words "expects," "promises," "anticipates," "estimates," "plans," "intends," "projects," "predicts," "believes," "may" or "should," and similar expressions, ar intended to identify forward-looking statements. These statements reflect the current view of the Company's management with respect to future events. Many factors could grounds the existent results, performance or achievements of the Company to be materially different from any future results, public presentation or achievements that may be expressed or implied by such forward-looking statements, including, only not special to, the following:


- The Company is still in the development stage and has non generated whatsoever revenues. From inception through June 30, 2008, it incurred net losses and negative cash flows from operating activities of some $31.3 million and $25.0 million, severally. Management believes that the Company volition continue to incur net losses and cash flow deficiencies from operating activities for the foreseeable future. Because it may accept years to develop, test and find regulatory favourable reception for a gene-based therapy product ahead it tin can be sold, the Company likely will continue to incur important losses for the foreseeable future. Accordingly, it may never be profitable and, if it does become profitable, it may be unable to sustain profitableness.


- At June 30, 2008, the Company had cash and johnny Cash equivalents of approximately $21.6 million, which management believes testament be sufficient to fund the Company's operations through at least December 31, 2009. The Company does not know whether additional financing testament be uncommitted when needed, or if available, testament be on acceptable or favorable terms to it or its stockholders.


- The Company will need to conduct future clinical trials for treatment of Parkinson's disease victimisation the Company's NLX engineering. If the trials prove unsuccessful, future operations and the potential for profitableness will be materially adversely affected and the business may non succeed.


- There is no assurance as to when, or if, the Company will be able to successfully receive approval from the FDA on its Investigational New Drug Application to start up a Phase 1 clinical trial for the discussion of epilepsy.


Other factors and assumptions not identified above could also causal agency the literal results to differ materially from those set away in the forward-looking statements. Additional information regarding factors that could cause results to differ materially from management's expectations is launch in the section nges in the Company's expectations.

Neurologix


More info

Thursday, 14 August 2008

Download Dion






Dion
   

Artist: Dion: mp3 download


   Genre(s): 

Blues
Rock
Pop

   







Discography:


El Azar Diablo
   

 El Azar Diablo

   Year: 2006   

Tracks: 11
Bronx in Blue
   

 Bronx in Blue

   Year: 2006   

Tracks: 14
Born to Be With You/Streetheart
   

 Born to Be With You/Streetheart

   Year: 2001   

Tracks: 20






Bridging the era betwixt late-'50s tilt and the British Invasion, Dion DiMucci (innate July 18, 1939) was one of the top edward D. White rock singers of his clip, shading the c. H. Best elements of doo guinea, teen paragon, and R&B styles. Some revisionists digest tested to cast him as a sort of early fair-haired soul fig, although he was in all likelihood more than aligned with pop/rock, at first as the atomic number 82 vocalist of the Belmonts, and then as a solo star. Drug problems slowed him down in the mid-'60s, thus far he made some surprisingly interesting progressions into blues-rock and folk-rock as the tenner wore on, culminating in a successful riposte in the recent '60s, although he was ineffective to confirm its commercial and artistic momentum for longsighted.


When Dion began recording in the late '50s, it was as the leash vocaliser of a mathematical group of friends world Health Organization american ginseng on Bronx street corners. Billing themselves as Dion & the Belmonts (Dion had released a previous unmarried with the Timberlanes), their first base few records were prime Italian-American doo ginzo; "I Wonder Why" was their biggest strike in this stylus. His biggest unmarried with the Belmonts was "A Teenager in Love," which pointed the agency for the slightly self-pitying, pained odes to adolescence and early adulthood that would characterise a good deal of his solo figure out.


Dion went solo in 1960 (the Belmonts did some more doo ginzo recordings on their own), moving from doo wop to more R&B/pop-oriented tunes with corking success. He handled himself with a politic, cocky simpleness on hits wish "The Wanderer," "Runaround Sue," "Lovers Who Wander," "Ruby Baby," and "Donna the Prima Donna," which throw off him as either the spurned, misunderstood tyke or the macho devotee, capable of manipulation anything that came his way (on "The Wanderer" peculiarly).


In 1963, Dion affected from Laurie to the larger Columbia tag, an connexion that started promisingly with a couple of big hits right turned the bat, "Ruby Baby" and "Donna the Prima Donna." By the mid-'60s, his diacetylmorphine habit (which he'd highly-developed as a stripling) was getting the topper of him, and he did little recording and playing for about five-spot days. When he did make it into the studio, he was moving in some surprisingly bluesy directions; although much of it was unnoted or unissued at the metre, it can be heard on the Bronx Blues reissue CD.


In 1968, he kicked diacetylmorphine and re-emerged as a gentle folk-rocker with a number four hit single, "Abraham, Martin and John." Dion would focus upon mature, present-day material on his late-'60s and early-'70s albums, which were released to convinced decisive feedback, if only tone down sales. The kinfolk phase didn't last long; in 1972 he reunited with the Belmonts and in the mid-'70s cut off a unsatisfying record with Phil Spector as producer. He's been transcription and performing evenhandedly oftentimes in the geezerhood that followed (sometimes singing Christian euphony), to indifferent commercial results. But his vital repp has risen steady since the early '60s, with many far-famed contemporary musicians showering him with congratulations and citing his influence, such as Dave Edmunds (wHO produced one of his periodical comeback albums) and Lou Reed (wHO guested on that track record). Dion continued to be active as the 21st c opened, releasing Déjà Nu in 2000, Under the Influence in 2005, and Bronx in Blue in 2006. His first-class honours degree major-label album since 1989's Yo Frankie, entitled Logos of Skip James, was released by Verve in 2007.






Wednesday, 6 August 2008

Los Cardenales Nuevo Leon

Los Cardenales Nuevo Leon   
Artist: Los Cardenales Nuevo Leon

   Genre(s): 
Latin
   



Discography:


24 Grandes Exitos   
 24 Grandes Exitos

   Year:    
Tracks: 24




 





New film follows the path of 300

Friday, 27 June 2008

Mickey Hart

Mickey Hart   
Artist: Mickey Hart

   Genre(s): 
Pop
   Folk
   Ethnic
   New Age
   



Discography:


Spirit Into Sound   
 Spirit Into Sound

   Year: 2001   
Tracks: 12


Supralingua   
 Supralingua

   Year: 1998   
Tracks: 12


Mystery Box   
 Mystery Box

   Year: 1996   
Tracks: 10


Planet Drum   
 Planet Drum

   Year: 1991   
Tracks: 13


At The Edge   
 At The Edge

   Year: 1990   
Tracks: 9


The Music Of Upper and Lower Egypt   
 The Music Of Upper and Lower Egypt

   Year:    
Tracks: 6




Mickey Hart is a drummer, an ethnomusicologist, and an author. He united the Grateful Dead as its second percussionist in 1967. In 1970, Hart left hand the Dead and cut the solo album Rolling Thunder in 1972, featuring various members of the Dead. Hart returned to the dance band in 1974. Hart's musical activities outside the Dead get been extended. In 1976, the Dead's Round Records pronounce released Diga by the Diga Rhythm Band, an early experimentation in worldbeat nuclear fusion reaction order in concert by Hart. His interaction with drummers from around the humanity sparked an enduring interest in the function of the brake drum in early cultures -- and a steadily expanding curiosity about non-Western musics. 1979 and 1980 power saw the outlet of two albums of music from the photographic film Revelation of Saint John the Divine Now, a great deal of it contributed by Hart. In 1983, Hart released albums under the head the World. These began with a reissue of Diga Rhythm Band (an record album by Babatunde Olatunji produced by Hart). Then came a series of albums of euphony Hart had recorded around the humanity. In 1989 Hart released Music to Be Born By, an record album based on the heartbeat of his boy in the uterus, and 1990 proverb the concurrent release of Hart's number one volume, Drumming at the Edge of Magic, and an record album, At the Edge. In 1991, some other volume and disk, both called Planet Drum, appeared. Both albums made the upper reaches of the newfangled age and humanity music charts. Supralingua followed in 1998, and two long time later Hart returned with Spirit into Sound. 2007 byword the release of Globular Drum Project with Zakir Hussain, Sikiru Adepoju, and Giovanni Hidalgo on Shout! Factory.






Thursday, 19 June 2008

50 Cent Compares Naked Fans To Prostitutes

50 Cent has compared the naked fans he regularly finds in his hotel room to prostitutes.

The hip-hop star - real name Curtis Jackson – insists he has never been tempted by his ready and willing groupies because they remind him of Amsterdam sex workers.

"I've been in hotel rooms, and girls were already there in the closet - naked. Hell, no! Are you kidding me? That's like Amsterdam,” he tells Vibe mag.   

"Amsterdam is fun for some people, but I don't want (no one) that costs $50. There's too many people that got $50!"

Friday, 13 June 2008

Coldplay follow Oasis' lead with Thursday album release today (June 12)

Coldplay's fourth studio album 'Viva La Vida or Death And All His Friends' is out today (June 12).

This Thursday release of the Brian Eno-produced record, the follow-up to the band's 2005 multi-platinum selling album 'X & Y', echoes Oasis, who also went for a midweek release for their third album 'Be Here Now'.

Released in August 1997, the Oasis album, much like Coldplay's current record, was highly anticipated by both music fans and critics.

Similar to 'Viva La Vida or Death And All His Friends', the Oasis record had a considerable pre-release build-up, which saw the band selling 420,000 copies on the first day.

Coldplay's new album has broken the iTunes pre-sale record - with pre-sales earlier this week outnumbering the rest of the Top 40 combined.

Have you bought the new Coldplay album? Or are you heading out to the shops today? If so NME.COM want your reviews.

Send them into news@nme.com with Coldplay in the subject line, and we'll put up the best ones.